肠道微生物群衍生代谢物对神经系统疾病的影响
Nishu Dalal1,2, Jyoti Jaiswal1, Manish Kushwaha1,3
1Gene Regulation Laboratory, National Institute of Immunology, New Delhi 110067, India.
ACS chemical neuroscience
|October 30, 2025
概括
肠道微生物群的代谢物,如TMAO和pCS影响大脑健康,导致神经炎症和神经系统疾病的认知衰退. 准这些代谢物为大脑健康提供了潜在的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 神经系统疾病 (NDs) 是一个主要的全球健康问题,经常出现神经退行.
- 肠-大脑轴是一个重要的通信网络,受到肠道微生物群代谢物的影响.
- 这些代谢物可以影响中枢神经系统 (CNS) 功能,并与NDs有关.
研究的目的:
- 探索肠道微生物群衍生代谢物在神经系统疾病中的作用.
- 了解这些代谢物影响神经炎症,氧化应激和认知功能的机制.
- 为了确定ND治疗的肠道微生物群中的潜在治疗点.
主要方法:
- 审查目前的研究,将肠道微生物群代谢物与NDs联系起来.
- 对关键代谢物的分析,如TMAO,pCS,4-EPS和IS.
- 讨论这些代谢物对血脑屏障和神经元健康的影响.
主要成果:
- 特定的代谢物 (TMAO,pCS,4-EPS,IS) 与神经炎症,氧化应激和认知衰退有关.
- TMAO破坏了血脑屏障的完整性,并促进神经炎症.
- 增加的pCS和4-EPS与诸如帕金森病,阿尔茨海默病和自闭症谱系障碍等疾病的认知障碍和行为变化相关.
结论:
- 肠道衍生代谢物显著影响神经健康和疾病进展.
- 通过饮食和补充剂 (益生菌,益生菌) 调节肠道微生物群是一种有前途的治疗途径.
- 需要先进的生物传感器来实时监测和早期干预与代谢物相关的神经疾病.
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