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一年身体质量指数的变化和随后的腰椎间盘的风险:基于人口的队列研究

Soichiro Masuda¹, Toshiki Fukasawa¹, Shuichi Matsuda²

¹Department of Pharmacoepidemiology, Kyoto University, Kyoto, Japan.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

|October 30, 2025

概括

体重指数 (BMI) 的变化与腰椎间盘 (LDH) 风险有关. 增加的BMI可能会增加LDH风险,但这种影响根据初始的BMI而异,建议个性化体重管理以预防.

科学领域:

整形外科整形外科整形外科
流行病学流行病学
公共卫生公共卫生

背景情况:

腰椎间盘 (LDH) 是背部疼痛和残疾的一个重要原因.
体重指数 (BMI) 是评估体重状况的常见指标,与各种健康状况有关.
了解BMI变化与LDH风险之间的动态关系对于预防策略至关重要.

研究的目的:

调查身体质量指数 (BMI) 一年变化与随后患腰椎间盘 (LDH) 的风险之间的关联.
探索潜在的剂量反应关系和基于基线BMI的效果修改.

主要方法:

一项基于日本行政索赔数据库的基于人口的队列研究.
包括超过400万没有LDH病史的个人接受年度健康检查.
分析使用多变量Cox比例危险模型,限制立方线,以评估BMI变化和LDH风险,并根据基线BMI类别进行子组分析.

主要成果:

在为期一年的随访期间,共记录了15099例LDH事件病例.
一年内BMI的较大增加与线性增加的LDH风险有关,特别是超过2%的变化.
值得注意的是,在基线BMI≥30kg/m2的个体中,BMI一年的增加矛盾地与LDH风险的降低有关.

结论:

一年内的BMI变化与LDH风险有显著的关联,这种关系取决于个体的基线BMI.
研究结果表明,根据基线BMI量身定制的体重管理策略可能在预防LDH方面发挥作用.
对个性化体重管理和运动治疗的进一步研究可以为LDH提供新的预防方法.

关键词:

这就是为什么BMI是BMI.体重指数 (Body Mass Index) 是一个指数.流行病学流行病学在 LDH 和 LDH 之间.腰椎椎间盘的发生有限制的立方线.风险风险风险

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