肺扩散能力变化与HRCT胸部和V / Q SPECT在COVID-19后短期和中期随访的发现之间的关系:前性队列研究 (安全研究)
Thora Wesenberg Helt1, Rie Skovly Thomsen2, Jan Christensen3
1Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, Copenhagen, 2100, Denmark.
European journal of nuclear medicine and molecular imaging
|October 30, 2025
概括
肺扩散能力 (DLCOc) 在COVID-19后12个月改善,尽管肺部异常持续存在. 这项研究随着时间的推移跟踪了COVID-19患者的肺功能和成像.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 传染病 传染病 传染病
背景情况:
- 肺扩散能力降低 (DLCOc) 是COVID-19的一个常见的继发性疾病.
- 这种减少通常与肺纤维化和通风透气异常有关.
- COVID-19严重程度,肺功能和成像发现之间的关系需要进一步调查.
研究的目的:
- 评估COVID-19初始严重程度与DLCOc降低在短期和中期随访中的关联.
- 为了确定HRCT上的纤维化类异常和V/Q SPECT上的呼吸系统障碍与DLCOc减少的相关程度.
主要方法:
- 153名COVID-19患者接受了肺功能测试,胸部HRCT和V / Q SPECT.
- 后续评估是在短期 (5.6个月) 和中间 (12.5个月) 间隔进行的.
- 患有COVID-19后续症状的患者被纳入中期随访.
主要成果:
- 在短期随访时观察到DLCOc的严重程度依赖的降低,该降低在中间随访后得到解决.
- 在两个随访点,HRCT显示了与疾病严重程度相关的地面玻璃不透明度和纤维化变化.
- V/Q SPECT显示了持续的呼吸系统异常,包括匹配和反向匹配的缺陷.
结论:
- 在COVID-19后的严重程度依赖的DLCOc减少显示,通过中间随访,自发恢复.
- 尽管DLCOc有所改善,但限制性呼吸系统障碍和HRCT相关的形态变化仍然存在.
- 早期COVID-19的严重程度会影响短期的肺功能恢复.
相关概念视频
Respiratory Volumes and Capacities
The respiratory system is responsible for the intake of oxygen and the expulsion of carbon dioxide from the body. Respiratory volumes describe the volume of air in the lungs at different phases of the respiratory cycle. Tidal volume is the air breathed in and out during normal, quiet breathing. Inspiratory reserve volume is the air that can be forcefully inspired beyond the tidal volume. In contrast, expiratory reserve volume refers to the air that can be expelled from the lungs after a normal...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
Pneumothorax-II
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
Radiological Investigation II: MRI and Ventilation Perfusion Scan
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Pulmonary Function Tests
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...


