相关实验视频
Updated: Jan 12, 2026
04:42
Bacterial Cellulose Spheres that Encapsulate Solid Materials
Published on: February 26, 2021
4.9K
将Saccharomyces boulardii封装成涂有肠道聚合物的糖颗粒
Karla Lilian Bailon-Barceinas1, Zacnite Sánchez-Portilla2, Alma Delia Román-Gutiérrez3
1Maestria en Ciencias Farmaceuticas, Departamento de Sistemas Biologicos, Universidad Autonoma Metropolitana, Unidad Xochimilco, Ciudad de Mexico, 04960, Mexico.
World journal of microbiology & biotechnology
|October 30, 2025
概括
这项研究开发了一种修饰释放系统,以保护Saccharomyces boulardii (S. boulardii) 在制造和胃通道期间. 肠膜系统增强了益生菌的活力,确保更多的活细胞到达肠道.
科学领域:
- 制药科学 制药科学
- 微生物学 微生物学
- 生物技术是生物技术.
背景情况:
- 益生菌的生存能力在制造和胃运输过程中经常受到损害.
- 丧失活力的益生菌细胞会降低治疗效果.
- 需要改善像Saccharomyces boulardii这样的益生菌的输送系统.
研究的目的:
- 制定一种修改释放系统来保护S. boulardii.
- 在制造和酸性条件下增强益生菌生存.
- 为了确保可行的S. boulardii的最佳输送到肠道.
主要方法:
- 在糖颗粒上叠加S. boulardii并涂上Eudragit® S12.5 (5%和10%).
- 颗粒被封装在硬的凝囊中.
- 评估了活力,体重变化,分解时间和在不同pH值下溶解.
主要成果:
- 在模拟的胃条件下,肠膜显著保护了S. boulardii的生存能力.
- 在酸性pH下没有发生释放;在性条件下观察到显著的释放 (20分钟内81-87%).
- 解体时间在药典限制范围内 (18分钟).
结论:
- 开发的修改释放系统有效地保持了S. boulardii的生存能力.
- 这种系统提供了一个有希望的替代品,可以增强益生菌向小肠的输送.
- 达到目标部位的活力增加的S. boulardii可能会改善治疗结果.
相关概念视频
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
188
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
188
01:24Oligosaccharide Assembly
3.5K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
3.5K