与代谢功能障碍相关的肥胖性肝病和心血管疾病-一种越来越大的威胁超越了肝脏
Mohammad Dawar Zahid1, Abhishek Lal2, Aysha Almas2
1Medical Student, Aga Khan University, Karachi, Pakistan.
Current atherosclerosis reports
|October 30, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 表明动脉样硬化心血管疾病 (ASCVD) 风险增加. 使用新生物标志物和治疗方法的早期检测和联合管理策略对于改善患者的治疗结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和动脉样硬化心血管疾病 (ASCVD) 经常同时存在.
- 目前尚不完全理解MASLD和ASCVD之间的双向病理生理联系.
- 关键机制包括胰岛素抵抗,脂质失调,炎症和内皮功能障碍.
研究的目的:
- 审查MASLD和ASCVD之间的关系.
- 讨论MASLD诱导的动脉动脉生成机制.
- 在MASLD群体中确定ASCVD风险分层的工具.
主要方法:
- 审查最近的队列研究 (过去五年).
- 评估新的生物标志物 (例如,阿波利波蛋白B,阿迪波基因).
- 评估先进的成像技术 (如冠状动脉CT血管造影).
主要成果:
- MASLD的严重程度与亚临床动脉样硬化和未来的心血管事件相关.
- 新的生物标志物和成像改善了风险预测,超出了传统因素.
- 新兴的治疗方法 (GLP-1 RAs,SGLT2抑制剂) 对MASLD和ASCVD都很有前途,尽管他类药物的使用受到肝脏安全问题的限制.
结论:
- MASLD既是ASCVD风险的标记物,也是中介物,因此需要综合查和管理.
- 将MASLD相关的生物标志物纳入心血管风险模型可以帮助早期检测.
- 未来的研究应该专注于联合代谢疗法的大规模试验,以获得双重肝脏和心脏的益处.
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