两个世界的桥梁:宿主微生物群在健康和调节失调方面交叉通话
Mahjabin Sanam1, Chowdhury Fatema Tuz Zohra Hossain1, Tahmida Binte Hyder1
1Department of Biochemistry and Microbiology, North South University, Bashundhara R/A, Dhaka, Bangladesh.
Innate immunity
|October 30, 2025
概括
肠道微生物群通过微生物代谢物来影响健康,这些代谢物调节免疫力和肠道屏障功能. 失衡 (失生症) 可以导致各种疾病,需要治疗干预来恢复微生物平衡.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群对于宿主生理学至关重要,通过复杂的相互作用产生代谢物并维持平衡.
- 微生物群组成或宿主相互作用的变化可能导致失生症,影响健康.
- 微生物代谢产物在调节免疫反应和肠道屏障完整性方面发挥着关键作用.
研究的目的:
- 审查微生物代谢物对免疫过程和肠道屏障完整性的调节作用.
- 探索如何破坏宿主信号通路和促进炎症.
- 突出治疗策略,以恢复肠道微生物群平衡.
主要方法:
- 对肠道微生物群,微生物代谢物和宿主微生物相互作用研究的文献综述.
- 对参与免疫调节和肠道平衡的信号通路的分析.
- 对失生症的治疗方法的检查.
主要成果:
- 微生物代谢物 (短链脂肪酸,托代谢物,胆酸,多胺) 显著调节先天性和适应性免疫力.
- 这些代谢物激活特定的受体 (TLRs,NODs,GPCRs,核受体,Wnt/β-catenin),影响免疫反应和屏障功能.
- 失生症破坏宿主信号传递,促进促炎途径,并导致胃肠道,代谢和神经系统疾病.
结论:
- 肠道微生物群及其代谢物对于维持生理平衡和免疫平衡至关重要.
- 失生症有助于一系列疾病,强调微生物平衡的重要性.
- 旨在恢复肠道微生物群平衡的治疗策略对于整体健康至关重要.
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