在人体体内,从大脑范围的概率性连接中,对人类上级结合体的分类
Matteo Diano1, Carlos Andrés Méndez2, Olga Dal Monte1,3
1Department of Psychology and Neuroscience Institute of Turin, University of Torino, Torino 10124, Italy.
概括
研究人员使用扩散核磁共振成像绘制了人类高级结肠 (SC) 线路的地图. 三个不同的SC子区域显示了独特的连接模式,揭示了它在感官集成和响应中的复杂作用.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 人类神经解剖学 人类神经解剖学
背景情况:
- 上层结肠 (SC) 是一个中脑结构,对于整合感官信息 (视觉,听觉,体感) 至关重要,以指导反射反应.
- 以前的研究,主要是在动物模型中,广泛描述了SC连接性,但人类的相关性仍然不清楚.
研究的目的:
- 用数据驱动方法研究人类SC的详细布线图.
- 识别人体SC中的不同亚区域及其独特的大脑范围连接模式.
- 将人类的SC连接性与动物模型的发现进行比较,并探索与人类新皮层扩张相关的适应性.
主要方法:
- 在200名参与者的队列中利用了扩散MRI和概率曲谱学.
- 开发了一种完全数据驱动的方法来分析voxel-wise SC连接.
- 推断的概率曲谱绘制,以在体内绘制SC的连接指纹.
主要成果:
- 根据它们的连接配置文件,在人类SC中确定了三个不同的子区域.
- 一个表面的SC划分与视觉皮层,杏仁体和后丘脑相连.
- 一个中间侧面划分连接到听觉/体感皮层和皮层,而一个深层划分连接到脑干和小脑.
结论:
- 人类的SC表现出显著的异质性在它的外部连接,与不同的子区域服务于不同的功能角色.
- 观察到的人类SC连接部分反映了保存的哺乳动物模式,但也表明皮层-中脑相互作用的适应.
- 这些发现为人类SC在感官处理和响应生成中的复杂作用提供了新的见解.
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