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Updated: Jun 19, 2026

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
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准裂谷热病毒聚合酶:抵抗机制和结构洞察力

Michal Král'1,2, Amiyaranjan Das3,4, Tomáš Kotačka1,2

  • 1Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.

ACS infectious diseases
|October 30, 2025
PubMed
概括

研究人员确定了裂谷热病毒 (RVFV) 聚合酶抑制剂,具有作为抗病毒疗法的潜力. 结构分析揭示了突变如何赋予耐药性,帮助未来的药物开发对这一重要的树冠病毒.

关键词:
L 蛋白质 L 蛋白质裂谷热病病毒病毒抗病毒药物 抗病毒药物聚合酶抑制剂的使用耐药性突变的突变结构洞察力 结构洞察力

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