长效注射PrEP可以大大降低洛杉矶县的艾滋病毒发病率:一项模拟研究
Aditya Khanna1, Francis Lee2, Katrina Schrode3
1Brown University School of Public Health.
Journal of acquired immune deficiency syndromes (1999)
|October 30, 2025
概括
长期的注射性暴露前预防 (PrEP) 显著降低了与男性发生性关系的年轻黑人男性的艾滋病毒发病率. 与每日口服PrEP相比,可注射PrEP的高保留率提供了与日常口服PrEP相比的可比或优越的HIV预防.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 艾滋病毒预防研究 预防研究
背景情况:
- 口服暴露前预防 (PrEP) 已经减少了艾滋病毒的发病率,但由于每日剂量,它面临着坚持的挑战.
- 与男性发生性关系的年轻黑人男性 (YBMSM) 不成比例地受到艾滋病毒的影响.
- 长效注射剂 (LAI) PrEP 是一个潜在的解决方案,可以改善坚持.
研究的目的:
- 模拟在洛杉矶县的YBMSM中引入LAI PrEP的影响.
- 评估不同的LAI PrEP吸收和保留率如何影响艾滋病毒传播.
- 为了比较LAI PrEP与口服PrEP在减少艾滋病毒发病率和流行率方面的有效性.
主要方法:
- 使用基于代理的网络模型 (ABNM),与实证数据进行校准.
- 模拟了10年的艾滋病毒传播动态,包括动态的性网络和艾滋病毒的进展.
- 模拟场景,不同比例的PrEP使用者转向LAI,不同程度的LAI保留.
主要成果:
- 与单独服用口服PrEP相比,LAI PrEP显著降低了艾滋病毒发病率和流行率.
- 对LAI PrEP的60%或更高的保留率产生了与口服PrEP相比或超过的减少.
- 当所有PrEP使用者转换为LAI时,HIV发病率下降了45%,其保留率为85%.
结论:
- 通过克服口服PrEP的坚持问题,LAI PrEP显示了在YBMSM中促进艾滋病毒预防的巨大潜力.
- 将LAI PrEP纳入公共卫生战略可以大幅减少艾滋病毒发病率.
- 莱普可以帮助结束艾滋病毒流行病在高优先级的人群,如YBMSM.
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