在光激活的PROTAC和光疗联合治疗癌症治疗方法的进展
Wei Zhang1, Shuai Li2, Hong Yuan3
1Central Hospital of Dalian University of Technology, Dalian, China; College of Laboratory Medicine, Dalian Medical University, Dalian, China.
European journal of medicinal chemistry
|October 30, 2025
概括
光激活的蛋白质分解向仿真体 (PROTACs) 通过精确地用光向瘤来增强癌症治疗,减少副作用. 这种创新方法结合了光疗和PROTACs,改善了瘤治疗和特异性.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 光动力学疗法 光动力学疗法
背景情况:
- 通过降解瘤蛋白质,传统的向蛋白质溶解的嵌合体 (PROTACs) 在癌症治疗中表现有前途.
- 临床翻译受到非目标效应,细胞吸收不良和瘤透程度有限的阻碍.
研究的目的:
- 审查用于癌症治疗的光激活PROTAC系统.
- 探索将光疗与PROTAC结合在一起的策略,以克服局限性.
主要方法:
- 开发可光切换和光的PROTACs用于时空控制.
- 光疗与PROTAC交付的整合,以获得协同作用的抗瘤效应.
主要成果:
- 光激活的PROTACs能够在瘤组织中精确激活,最大限度地降低目标外毒性.
- 这些系统增强治疗特异性,减少副作用.
- 与光疗相结合,可以提供协同作用的瘤治疗.
结论:
- 光激活的PROTACs代表了癌症治疗的有希望的进步.
- 这种方法克服了传统PROTACs的局限性,提高了临床适用性.
- 与光疗的协同治疗有可能改善癌症患者的治疗结果.
更多相关视频
07:24Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal
Published on: September 12, 2025
454
13:17In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
Published on: September 29, 2023
2.9K
相关概念视频
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
02:50Combination Therapies and Personalized Medicine
5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
01:27Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
01:30Cancer Vaccines
945
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
945
02:56Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K