在白血病中发作和的风险
Ashley N Hackett1, Helena Yan2, Katie Liu3
1Division of Pediatric Neurology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Texas Scottish Rite Hospital for Children, Dallas, Texas.
Pediatric neurology
|October 30, 2025
概括
发作在白血病中很常见,大多数受影响的儿童患有发作. 年龄和EEG异常,如焦点减速和形放电,预测了发作风险,需要有针对性的监测策略.
科学领域:
- 神经学 神经学
- 儿科神经学 儿科神经学
- 神经遗传学 神经遗传学
背景情况:
- 对于白血病发作中的发作和仍然不太了解.
- 白血病是一组罕见的遗传性疾病,影响大脑中的髓蛋白.
- 了解发病率和风险因素对于患者管理至关重要.
研究的目的:
- 确定全国范围的儿科白血病患者队列中发作和的流行率.
- 确定与发作和风险增加相关的因素.
- 在这个人群中量化耐火性发作的流行率.
主要方法:
- 从2013年至2020年间,在八个中心对704名被诊断患有白血病的儿科患者进行了回顾性数据分析.
- 纳入标准:年龄在18岁以下的患者,诊断为白血病.
- 收集的数据包括年龄,诊断,EEG发现以及发作/状态.
主要成果:
- 29%的患者经历了至少一次发作;80%的人患上了.
- 脑电图异常在患有的患者 (84%) 和没有的患者 (54%) 中明显更常见.
- 发作风险的增加与年龄,一般性和焦点性发作排放以及焦点减缓有关.
结论:
- 年龄,焦点减缓和形出血是儿科白血病发作中的重要发作预测因素.
- 患有普遍性排放的患者比患有焦点性排放的患者面临更高的发作风险.
- 需要针对发作和的有针对性的监测策略,考虑到基于白血病变异类型的变化.
相关概念视频
Epilepsy and Seizures: Overview
1.1K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.1K
Seizures: Classification
1.3K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.3K
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
804
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
804
Antiepileptic Drugs: Potassium Channel Activators
620
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
620
Antiepileptic Drugs: Calcium Channel Blockers
1.1K
Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
1.1K
Antiepileptic Drugs: Sodium Channel Blockers
1.6K
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
1.6K


