在Pfizer-BioNTech的COVID-19疫苗接种后,状平原色素逆转:一个罕见的病例报告
Halkawt Babarasul Ahmed1, Jeza Muhamad Abdulaziz2, Hawnaz Atta Karim3
1Biomedical Sciences, Komar University of Science and Technology, Sulaymaniyah, Kurdistan region, Iraq.
Diagnostic microbiology and infectious disease
|October 30, 2025
概括
一种罕见的皮肤疾病,Lichen Planus Pigmentosus Inversus (LPPI),在一个妇女在接种了瑞-生物科技COVID-19疫苗的第二剂量后发生. 用局部塔克罗利斯和皮质类固醇治疗导致色素减少.
科学领域:
- 皮肤病学 皮肤病学
- 疫苗学 疫苗学 疫苗学
- 病理学 病理学 病理学
背景情况:
- 斑 (Lichen Planus Pigmentosus Inversus,简称LPPI) 是一种罕见的皮肤病,其特征是多颜色斑块和斑块.
- 针对COVID-19疫苗接种,特别是mRNA疫苗接种,已经对潜在的皮肤不良事件进行了调查.
- mRNA COVID-19 疫苗与皮肤病之间的关联是一个新兴的研究领域.
研究的目的:
- 报告在瑞-生物科技COVID-19疫苗接种后出现的一例状平原色素逆向 (LPPI).
- 突出临床表现,组织病理学发现和与疫苗相关的LPPI的管理.
- 提高医疗保健提供者对这种罕见的疫苗接种后不良影响的认识.
主要方法:
- 一个30岁的女性出现了特征性皮肤病变的病例报告.
- 临床检查和组织病理学确认LPPI.
- 用局部0.1%的塔克罗利莫斯和皮质类固醇治疗,随访时间为两个月.
主要成果:
- 该患者在第二剂瑞-生物科技COVID-19疫苗接种后两周内出现了LPPI.
- 组织病理学证实了LPPI在受影响的区域 (下,乳腺下,股沟).
- 颜色在治疗三周内显著下降,在两个月的随访中没有新的病变.
结论:
- 状斑 (Lichen Planus Pigmentosus Inversus,简称LPPI) 是mRNA COVID-19疫苗接种后的一种潜在的,尽管很少见的不良反应.
- 这一案例强调了皮肤科医生需要考虑LPPI患者的疫苗相关病因.
- 及时识别和适当的管理,包括局部疗法,可以导致疫苗相关的LPPI的良好结果.
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