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人类细胞染色体P4502C8将repaglinide代谢成4'-hydroxyrepaglinide,而不是3'-hydroxyrepaglinide

Raman Sharma1, Amanda Balesano1, Angela C Doran1

  • 1Pfizer Inc., Groton, Connecticut.

Drug metabolism and disposition: the biological fate of chemicals
|October 30, 2025
PubMed
概括

之前的研究错误地确定了repaglinide的主要代谢物. 这项研究纠正了结构,显示基化发生在4位,而不是3位,影响了CYP2C8活性研究.

关键词:
细胞染色体P4502C8C8的使用情况.核磁共振光谱法 (NMR) 是一种光谱法.这是一种Repaglinide.

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