多发性硬化症患者对疲劳的非药物干预措施的比较有效性:系统性审查和网络元分析
Hui Chang1, Xuexue Wang2, Yanru Shi3
1Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China.
International journal of nursing studies
|October 30, 2025
概括
综合干预,针,按摩,认知行为疗法,运动和电子健康是治疗多发性硬化症 (MS) 疲劳的有效非药物治疗方法. 综合干预似乎是最有效的改善MS疲劳.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 基于证据的实践.
背景情况:
- 疲劳显著影响多发性硬化症 (MS) 患者的生活质量.
- 非药物疗法为MS疲劳提供了药物治疗的替代方案.
- 对MS疲劳的最佳非药物干预需要进一步澄清.
研究的目的:
- 系统地比较各种非药物干预措施的有效性,以减少MS患者的疲劳.
- 确定最有效的非药理方法来管理MS相关的疲劳.
主要方法:
- 在七个数据库中进行了全面的文献搜索,截至2024年5月.
- 分析了涉及9项非药物干预的73项随机对照试验 (RCT).
- 使用网络元分析来评估干预措施的相对有效性,并使用Cochrane偏见评估工具2.0.0评估质量.
主要成果:
- 与对照组相比,运动治疗,认知行为治疗,针/按摩,电子健康和联合干预措施在MS疲劳方面表现出显著的改善.
- 综合干预 (SMD = -0.79) 显示了最大的效果大小,表明更高的疗效.
- 针对每个干预措施,报告了特定效应大小 (SMD) 和置信区间 (CI).
结论:
- 多种非药物干预措施,包括联合疗法,针/按摩,认知治疗,运动和电子健康,对于改善MS疲劳是有效的.
- 综合干预措施成为潜在的最有效的策略来缓解MS疲劳.
- 这些发现提供了关键的证据,以指导临床实践和MS疲劳的治疗决策.
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