Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
Stem Cell Niche01:26

Stem Cell Niche

6.2K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A transcriptomic microglia taxonomy across mouse and human pathologies.

Nature immunology·2026
Same author

A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer's disease.

Acta neuropathologica·2026
Same author

Correction: Preserved fascicular architecture predicts neuroma pain: a morphometric study.

Acta neuropathologica communications·2026
Same author

Alterations in cerebrospinal fluid levels of myelin- and oligodendrocyte-related proteins in sporadic Creutzfeldt-Jakob disease.

Acta neuropathologica communications·2026
Same author

Unlocking microglia pyroptosis in a model of type I interferon-driven neuroinflammation: lessons from Rnaset2<sup>-/-</sup> mice.

Cell death & disease·2025
Same author

Complement C4d Informs the Differential Diagnosis of Inflammatory Demyelinating CNS Diseases.

Neurology(R) neuroimmunology & neuroinflammation·2025

相关实验视频

Updated: Jan 12, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.9K

单细胞空间转录形状分析定义了慢性活跃多发性硬化病变中的病原性炎症利基.

Ruoqing Feng1, Lena Spieth1, Lu Liu1

  • 1Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany; German Center for Neurodegenerative Diseases, Munich, Germany.

Immunity
|October 30, 2025
PubMed
概括

研究人员在活跃的多发性硬化症 (MS) 病变中绘制了免疫细胞的地图,揭示了脂代谢微质驱动持续的神经炎症. 准脂质代谢在小鼠模型中减少了炎症和脱髓化,为MS提供了新的治疗途径.

关键词:
CD8+ T 细胞 CD8+ T 细胞CD8+组织内存T细胞 - 组织内存T细胞格利亚 (Glia) 是一个.脂质 脂质 脂质 是一种微质细胞中的微质细胞多发性硬化症多发性硬化症骨髓蛋白是什么意思 骨髓蛋白是什么意思神经炎症是一种神经炎症.空间转录学 空间转录学

更多相关视频

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
08:49

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

2.4K
Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
09:35

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

10.6K

相关实验视频

Last Updated: Jan 12, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.9K
Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
08:49

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

2.4K
Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
09:35

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

10.6K

科学领域:

  • 神经免疫学 神经免疫学
  • 细胞和分子神经科学

背景情况:

  • 分区性炎症驱动多发性硬化症 (MS) 的进展.
  • 慢性活跃多发性硬化病变中持续性炎症背后的机制尚未完全理解.

研究的目的:

  • 创建慢性活跃多发性硬化病变内的免疫的高分辨率空间和分子地图集.
  • 阐明特定免疫细胞相互作用和代谢途径在维持MS中神经炎症中的作用.

主要方法:

  • 结合单核RNA测序 (snRNA-seq) 与多重错误强大的光 in situ杂交 (MERFISH) 来绘制MS病变的细胞和分子特征.
  • 利用实验性自身免疫脑膜炎 (EAE) 的小鼠模型来研究微质和脂质代谢的功能.
  • 在微质中遗传删除的ATP结合盒载体ABCA1/G1和药理上向的固醇代谢.

主要成果:

  • 在病变边缘中确定了CD8+ T细胞,与炎症的微质细胞相关,表现出干扰素反应和改变的脂质代谢.
  • 在微质中删除ABCA1 / G1导致脂质储存的细胞增加,并在EAE小鼠中放大了炎症.
  • 在EAE模型中,药理抑制固醇代谢减少了泡细胞的形成和炎症性脱化.

结论:

  • 功能障碍的,储存脂质的微质细胞有助于慢性活性MS病变中的持续性神经炎症.
  • 准微质脂质代谢是一种潜在的治疗策略,可以缓解多发性硬化症的炎症和脱髓化.