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单细胞空间转录形状分析定义了慢性活跃多发性硬化病变中的病原性炎症利基.

Ruoqing Feng1, Lena Spieth1, Lu Liu1

  • 1Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany; German Center for Neurodegenerative Diseases, Munich, Germany.

Immunity
|October 30, 2025
PubMed
概括

研究人员在活跃的多发性硬化症 (MS) 病变中绘制了免疫细胞的地图,揭示了脂代谢微质驱动持续的神经炎症. 准脂质代谢在小鼠模型中减少了炎症和脱髓化,为MS提供了新的治疗途径.

关键词:
CD8+ T 细胞 CD8+ T 细胞CD8+组织内存T细胞 - 组织内存T细胞格利亚 (Glia) 是一个.脂质 脂质 脂质 是一种微质细胞中的微质细胞多发性硬化症多发性硬化症骨髓蛋白是什么意思 骨髓蛋白是什么意思神经炎症是一种神经炎症.空间转录学 空间转录学

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