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在非洲和欧洲后裔中使用OCT和OCTA检测青光眼进展时间

Jo-Hsuan Wu¹, Takashi Nishida², Sasan Moghimi²

¹From the Edward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center (J.-H.W.), New York, New York.

American journal of ophthalmology

|October 30, 2025

概括

使用光学连贯断层扫描 (OCT) 和OCT血管扫描 (OCTA) 检测青光瘤进展时间显示,非洲 (AD) 和欧洲血统 (ED) 个体之间没有种族差异. 在这两组中,OCT血管图检测出进展速度比OCT更快.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
玻璃眼研究研究玻璃眼研究

背景情况:

玻璃眼是全球不可逆转的失明的主要原因.
早期发现青光眼的进展对于及时干预和维护视力至关重要.
光学连贯断层扫描 (OCT) 和OCT血管扫描 (OCTA) 是用于监测玻璃眼的先进成像技术.

研究的目的:

为了比较非洲血统 (AD) 和欧洲血统 (ED) 个体之间检测青光眼进展的时间.
评估OCT和OCT血管学 (OCTA) 在检测随着时间的推移而发生的青光斑进展方面的性能.
评估OCT和OCTA在青光眼监测中的有效性,以评估潜在的种族差异.

主要方法:

这是一项回顾性队列研究,利用了来自DIGS的诊断创新研究 (DIGS) 的数据.
包括至少2年和4次OCT和OCTA成像访问的AD和ED光眼病患者.
基于线性混合效应模型衍生变化估计的计算机模拟,以评估在标准化和现实场景下检测进展的时间.

主要成果:

在标准化模拟中,在使用OCT或OCTA的AD和ED个体之间没有观察到明显的种族差异,以检测青光眼进展的时间.
现实世界的模拟表明,OCTA检测到AD的4.3年和ED的3.9年的进展,而AD的7.0年和OCT的ED的5.1年相比,OCTA检测到AD的4.3年和ED的3.9年.
与OCT相比,OCTA在两个种族群体中表现出更短的进展检测时间 (0.4-2.6年差异) 和更高的进展率.

结论:

计算机模拟表明,使用OCT和OCTA的AD和ED个体之间在青光眼进展检测时间中没有种族差异.
在两种种族群体中,OCTA始终显示出比OCT更短的时间和更高的进展检测率.
虽然需要进一步的临床验证,但OCTA可以作为一个有价值的OCT辅助工具,用于监测不同人群中的青光眼进展.

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