Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Regulation of Metabolism01:19

Regulation of Metabolism

11.4K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.4K
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

6.4K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
6.4K
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

3.8K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
3.8K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

4.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.8K
What is Glycolysis?00:56

What is Glycolysis?

176.0K
Overview
Cells make energy by breaking down macromolecules. Cellular respiration is the biochemical process that converts "food energy" (from the chemical bonds of macromolecules) into chemical energy in the form of adenosine triphosphate (ATP). The first step of this tightly regulated and intricate process is glycolysis. The word glycolysis originates from the Latin glyco (sugar) and lysis (breakdown). Glycolysis serves two main intracellular functions: generating ATP and generating...
176.0K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Thyroid hormone activation drives fibroblast identity and tumor remodeling in cutaneous squamous cell carcinoma.

Cell reports·2026
Same author

Pik3ip1 mediates thyroid hormone-dependent regulation of the PI3K/Akt/mTOR axis in muscle atrophy.

Molecular metabolism·2026
Same author

Dipeptidyl peptidase 3 sets the threshold for immune activation and survival during experimental bacterial infection.

Nature communications·2026
Same author

Cardiometabolic and renal complications of obesity: an updated comprehensive overview by SIO - Campania region.

Minerva endocrinology·2026
Same author

Thyroid hormones and metabolic flexibility: tissue-specific control of energy homeostasis.

Frontiers in physiology·2026
Same author

Voltage-gated potassium channels mediate thyroid hormone control of skeletal muscle excitability.

The Journal of physiology·2026

相关实验视频

Updated: Jan 12, 2026

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping
09:20

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping

Published on: March 23, 2022

2.5K

葡萄糖限制通过调节线粒体活动和脂解来调节骨质母细胞的功能.

Ciro Menale1, Concetta Sozio1, Giuliana La Rosa1

  • 1Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.

The Journal of nutritional biochemistry
|October 30, 2025
PubMed
概括

葡萄糖限制通过促进骨质母细胞中的脂质利用来增强骨质生成. 这种代谢转变在低葡萄糖条件下支持骨细胞功能,对于糖尿病等疾病至关重要.

关键词:
葡萄糖是一种葡萄糖.脂质 脂质 脂质 是一种脂质溶解 脂质溶解是一种线粒体中的线粒体.骨质母细胞是骨质母细胞.

更多相关视频

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.7K
Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

3.7K

相关实验视频

Last Updated: Jan 12, 2026

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping
09:20

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping

Published on: March 23, 2022

2.5K
Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.7K
Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

3.7K

科学领域:

  • 骨生物学和新陈代谢
  • 细胞生物能学 细胞生物能学
  • 营养物质感应 营养物质感应

背景情况:

  • 骨质细胞 (OB) 的生物能量和功能对骨健康至关重要.
  • 机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械机械

研究的目的:

  • 研究葡萄糖限制对骨质细胞代谢和功能的影响.
  • 在低血糖条件下,阐明脂质利用在骨质母细胞中的作用.

主要方法:

  • 在生理 (5.5 mM) 和低 (1.25 mM) 葡萄糖条件下培养了MC3T3-E1骨质细胞和初级骨质细胞 (pOB).
  • 进行了细胞增殖,迁移,克隆原性和骨质生成测试.
  • 分析了线粒体形态,氧化能力,ATP生产,脂滴积累和与脂解相关的基因表达.
  • 药理干预措施 (Etomoxir,ATGListatin) 用于调节脂质代谢.

主要成果:

  • 低血糖 (LG) 降低了OB增殖,迁移和克隆原性,但增强了骨质生成.
  • LG诱导了线粒体延长,增加了氧化能力,并增加了ATP的产生.
  • 有证据表明,在LG条件下,OBs利用脂质,由减少的脂质滴和升调的脂解基因表明.
  • 在LG条件下抑制脂质利用 (Etomoxir) 或脂解 (ATGListatin) 损害骨质生成.

结论:

  • 骨质细胞功能受到营养燃料的可用性显著调节.
  • 脂质利用是骨质细胞代谢的一个基本过程,特别是在葡萄糖有限的条件下.
  • 这些发现强调了脂质代谢对骨健康的重要性,特别是在糖尿病等代谢疾病中.