孕产妇阿司匹林治疗对新生儿表观遗传模式的影响
Dante Varotsis1, Suhita Gayen Nee Betal2, Sankar Addya3
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, United States.
American journal of perinatology
|October 30, 2025
概括
孕妇低剂量阿司匹林 (LDA) 在怀孕期间使用会改变新生儿带血DNA甲基化,影响炎症和心血管路径. 需要进一步的研究来探索对婴儿健康的潜在保护作用.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 围产儿医学 围产儿医学
- 发展生物学 发展生物学
背景情况:
- 低剂量阿司匹林 (LDA) 建议用于预防高风险怀孕中的高血压妊娠障碍 (HDP).
- 孕产妇的HDP与带血表观遗传变化有关,但孕产妇的LDA对新生儿表观遗传在健康高风险怀孕中的影响尚不清楚.
研究的目的:
- 为了调查母亲在怀孕期间暴露于LDA是否会改变DNA甲基化在新生儿的带血液.
- 为了确定这些甲基化变化是否影响与慢性疾病发展相关的关键途径.
主要方法:
- 从新生儿收集带血液样本,其中有 (n=13) 和没有 (n=10) 在子宫内接触LDA.
- 排除标准包括孕产妇的HDP,COVID-19和胆 ?? 膜炎.
- 进行全基因组DNA甲基化分析,使用Illumina甲基化EPIC试验.
主要成果:
- 与对照对象相比,在暴露于LDA的新生儿中发现了155个不同的甲基化位点 (81个高甲基化,74个低甲基化).
- 关键受影响的途径包括Th1/Th2信号传递和M1巨细胞激活.
- 与LDA暴露相关的基因影响了心脏和脏系统.
结论:
- 产妇在子宫中的LDA暴露与新生儿带血中的差异性DNA甲基化有关.
- 这些表观遗传变化与炎症,心脏和脏毒性途径有关.
- 需要进一步的研究来探索母乳LDA对新生儿表观遗传学和长期健康规划的潜在保护性影响.
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