肠道衰竭中的老年综合征:中年成人患者的加速衰老现象?
Darío A Sandoval-Valdez1, Ana Luz Del Carmen Reyes Ramírez1, Aurora Elizabeth Serralde Zúñiga1
1Servicio de Nutriología Clínica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Ciudad de México, Mexico.
Clinical nutrition ESPEN
|October 30, 2025
概括
慢性肠衰竭 (CIF) 患者经历过早衰老和老年综合征的高患病率,甚至在65岁之前. 这凸显了CIF作为加速衰老和相关健康并发症的潜在模型.
科学领域:
- 老年学是指老年学的学科.
- 胃肠病学 胃肠病学
- 内部医学 内部医学
背景情况:
- 衰老涉及到分子和细胞的变化 (衰老的特征),导致老年综合征.
- 慢性肠衰竭 (CIF) 与衰老有共同的机制,可能会加剧并发症.
- 没有研究评估了CIF的门诊亲肠道营养患者的老年综合征.
研究的目的:
- 评估40至70岁的成年人中老年综合征的存在和负担,在门诊亲肠营养中使用CIF.
- 调查CIF与过早衰老之间的联系.
主要方法:
- 对14名患有CIF的成年患者 (40-70岁) 进行了综合老年学评估,这些患者接受了家庭亲肠道营养.
- 评估的综合征包括多病症,虚弱,认知衰退,抑郁,跌倒和功能依赖.
- 使用表观遗传时钟 (PhenoAge) 将表型年龄与时间年龄进行比较.
主要成果:
- 所有参与者 (100%) 患有至少五种老年综合征,57.1%患有十种或以上.
- 现型年龄 (67.5岁) 超过了年代年龄 (58.3岁),表明过早衰老.
- 多药性 (92.9%),功能性依赖性 (64.3%基本,92.9%工具性),虚弱 (78.6%-92.9%),肉眼症 (42.9%),跌倒 (21.4%),抑郁症 (57.1%) 和认知衰退 (92.9%) 的高患病率.
结论:
- 慢性肠衰竭患者表现出高负担的老年综合征,表明过早衰老.
- CIF可以作为一种病理模型,其中代谢,炎症,表观遗传和社会因素融合,导致中年成人加速衰老.
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