在精神分裂症中,受损的说话诱导的抑制预测了下降的代理和幻觉严重性的预测
Songyuan Tan1, Yingxin Jia1, Miriam Mathew1
1Department of Psychiatry, University of California, San Francisco, CA.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|October 30, 2025
概括
精神分裂症患者有代理缺陷,影响现实和语音监测. 精神分裂症的听觉反应受损导致错误地将内部语音归因于外部,恶化幻觉.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 机关,即产生行动和思想的感觉,在精神分裂症 (SZ) 中受损.
- 这些代理缺陷有助于现实监控和语音监控困难,包括幻觉.
- 在SZ中,幻觉可能是由于错误地将自我生成的语音归为外部语音.
研究的目的:
- 用现实监测和语音监测任务来调查精神分裂症中的代理缺陷.
- 通过磁脑图 (MEG) 检查代理人的神经相关物.
- 确定语音受损监测是否可以预测SZ患者的幻觉严重程度.
主要方法:
- 磁脑电图 (MEG) 用于在现实监测和语音监测任务中评估代理.
- 参与的是健康对照组 (HC) 和SZ患者 (N=30个).
- 在语音生产和听力过程中测量了M100听觉皮质反应的说话诱导抑制 (SIS).
主要成果:
- 与HC相比,SZ患者在现实监测期间表现出自我和外部代理机构受损.
- SZ患者显示SIS减弱,听力和说话条件之间的M100差异较小.
- 在SZ患者中,削弱的SIS与增加的幻觉严重程度相关.
结论:
- 精神分裂症与听觉过程中听觉皮质M100神经反应退化有关.
- 在SZ中受损的SIS反映了受损的听觉感官预测.
- 这种障碍增加了错误归因内言的可能性,导致代理干扰和严重幻觉.
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