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脑水含量的急性和短暂变化是由单次电治疗会话引起的

Akihiro Takamiya¹, Frank Riemer², Vera Jane Erchinger³

¹Department of Neurosciences, Neuropsychiatry, Leuven Brain Institute, KU Leuven, Leuven, Belgium; Hills Joint Research Laboratory for Future Preventive Medicine and Wellness, Keio University School of Medicine, Tokyo, Japan; Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Bergen, Norway.

Brain stimulation

|October 30, 2025

概括

抑郁症的电疗法 (ECT) 导致大脑细胞外水的暂时增加. 这些微观结构性脑部变化是可逆的,并不表明长期损伤.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
精神病学是一个精神病学.

背景情况:

电疗法 (ECT) 对严重抑郁症有效,但引起了人们对潜在的不良大脑影响的担忧.
单次ECT对大脑微观结构和长期生物效应的影响尚不清楚.

研究的目的:

使用扩散核磁共振 (MRI) 进行电疗法 (ECT) 后的纵向微观结构性大脑变化的调查.
为了确定ECT诱导的发作是否会导致持久的不良生物效应或短暂的生理变化.

主要方法:

在25名患有抑郁症的个人中,在第一次ECT会议前后对扩散MRI指标进行了纵向分析.
对照组包括接受麻醉的个人和健康的对照组,以考虑混因素.
一个多分区模型评估了细胞外自由水和细胞分区的变化.

主要成果:

一次单一的ECT会话暂时增加了海马附近的周周和下皮层区域的细胞外自由水.
这些观察到的脑水转移在对照组中并不存在,并在14天内消失.
没有检测到细胞毒性胀或细胞损伤的证据,变化与触发后重定位时间无关.

结论:

ECT诱导的发作会导致特定大脑区域的细胞外含水量暂时增加.
这些大脑水的转移是可逆的,并且似乎不代表永久的大脑组织损伤.
研究结果表明,ECT不太可能对大脑微观结构产生持久的不良生物学影响.

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Electroconvulsive Therapy

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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...