功能性腹部膨胀与肠道微生物群失调和肠道屏障功能的改变有关:实验证据
Deniz Sunnetci Akkoyunlu1, Altay Celebi2, Bahriye Gur1
1Department of Medical Genetics, Faculty of Medicine, Kocaeli University, Kocaeli, Türkiye.
In vivo (Athens, Greece)
|October 30, 2025
概括
功能性腹部膨胀 (FAB) 与显著的肠道微生物群失衡和肠道炎症标志物增加有关. 这些发现突显了FAB中可测量的生物变化,支持了以微生物群为重点的治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 功能性腹部膨胀 (FAB) 是一种常见的胃肠道疾病.
- 它的潜在生物机制,特别是肠道微生物群和肠道屏障功能,需要进一步阐明.
研究的目的:
- 在FAB患者的肠道微生物群变化的特征.
- 评估FAB中的肠道屏障标记物.
- 探索有助于FAB的生物机制.
主要方法:
- 分析了42名FAB患者的便样本,使用了基因间间隔特征 (16S-23S rDNA).
- 通过实时PCR对关键细菌种群的量化.
- 使用ELISA测量胃肠道免疫和透性标记物 (calprotectin,sIgA,zonulin,α1-antitrypsin) 的测量.
主要成果:
- 在90.5%的患者中观察到显著的肠道失调 (失调指数≥15).
- 减少了微生物多样性和Firmicutes/Bacteroidetes比率.
- 有益细菌的减少 (例如,Faecalibacterium prausnitzii,Akkermansia muciniphila) 和致病性细菌的增加 (例如,蛋白质细菌) 是普遍存在的.
- 增加的calprotectin和sIgA表明粘膜免疫激活;增加的zonulin和α1-antitrypsin表明潜在的屏障功能障碍.
结论:
- FAB与深度肠道微生物群失生症和改变的粘膜免疫反应有关.
- 这些发现表明FAB病理生理学的可测量的生物变化.
- 结果支持微生物群分析和针对FAB的向治疗策略的临床相关性.
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