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化学疗法诱导的周围神经毒性诊断:一个范围审查

Valentina Cerrone¹, Dalila Esposito¹, Mario Montedoro¹

¹Anesthesia and Pain Medicine, Department of Medicine, Surgery and Dentistry Scuola Medica Salernitana, University of Salerno, Baronissi, Italy.

In vivo (Athens, Greece)

|October 30, 2025

概括

诊断化疗诱导的外围神经病变 (CIPN) 缺乏标准化的方法. 本综述绘制了当前诊断工具的地图,强调了在临床实践中需要验证和可靠的方法,以更好地监测患者.

科学领域:

在瘤学瘤学.
神经学神经学
临床诊断临床诊断临床诊断

背景情况:

化疗诱导的周围神经病变 (CIPN) 是癌症治疗的常见和衰弱的副作用.
准确识别,评估和监测CIPN对于患者管理和治疗适应至关重要.

研究的目的:

系统地绘制成年癌症患者化疗诱导的周围神经病变 (CIPN) 诊断方法的文献.
确定CIPN的诊断和监测当前的做法和差距.

主要方法:

从2000年到2024年,在主要数据库 (PubMed,科学网,Scopus,Cochrane图书馆) 进行了全面的文献搜索.
包括的研究评估了各种诊断方法:临床评估,患者报告的结果,生物标志物,神经生理测试和数字工具.
使用Joanna Briggs研究所的批判性评估工具来评估方法质量.

主要成果:

包括29项研究,揭示了研究设计和验证的显著异质性.
患者报告的结果 (例如,EORTC QLQ-CIPN20,NCI-CTCAE) 是最常见的.
生物标志物,神经生理测试,先进的成像和数字技术也被利用,但应用和验证程度不同.

结论:

目前CIPN的诊断方法缺乏标准化和验证,限制了临床效用.
对于开发和验证可靠,可重复和实用的工具来进行常规的CIPN诊断和监测是非常必要的.
综合主观和客观措施的多模式方法越来越有趣,但需要进一步改进.

关键词:

化疗诱导的周围神经病变癌症癌症癌症癌症癌症神经毒性的作用.疼痛疼痛疼痛疼痛审查审查审查审查审查审查

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