偶发的眼球表面状瘤在pterygia:一个系统的审查和元分析
Andrew Mihalache1, Ryan S Huang1, Michael Balas2
1Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
The British journal of ophthalmology
|October 30, 2025
概括
这项研究发现,在pterygium病例中,眼表面状瘤 (OSSN) 的患病率为1.32%,受紫外线暴露和接近赤道的影响. 由于pterygium和OSSN之间的重叠特征,诊断挑战仍然存在.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 区分pterygium与眼表面状瘤 (OSSN) 对于适当的患者管理至关重要.
- 在临床诊断的菌病中,偶然发生的OSSN会给诊断带来挑战.
研究的目的:
- 为了评估偶发性OSSN在pterygium病例中的综合流行率.
- 为了确定与pterygia中偶然的OSSN相关的风险因素.
主要方法:
- 系统的文献搜索 欧维德·恩贝斯,MEDLINE,科克伦图书馆和科学网络 (2000年1月至2025年2月).
- 包括具有≥100个经过基因病理学分析的pterygia的研究.
- 随机效应元分析用于流行率和风险因素评估,包括对地理和紫外线暴露影响的元回归.
主要成果:
- 在12项研究 (8688个标本) 中,偶发性OSSN的综合患病率为1.32% (95% CI 0.41%至4.21%).
- 较低的患病率与距离赤道的距离增加相关 (OR 0.49),而较高的患病率与更大的紫外线暴露相关 (OR 2.20).
- 在年龄,性别,病变位置或肺类型 (原发性与复发性) 中,在OSSN和良性肺之间没有观察到显著的差异.
结论:
- 分析表明,在菌体中,偶发性OSSN的患病率为1.32%,而紫外线辐射和赤道附近的位置有很大影响.
- 低至非常低的确定性证据突显出由于临床特征重叠而导致的诊断困难.
- 可能需要进一步的研究来完善诊断标准和管理策略.
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