儿童肠道微生物组与通过功能连接体在学龄时内化症状有关
Francesca R Querdasi1, Jessica P Uy2,3, Jennifer S Labus4,5,6,7
1Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA. frq@ucla.edu.
Nature communications
|October 31, 2025
概括
早期的肠道微生物,特别是Clostridiales和Lachnospiraceae,与儿童内化症状有关. 这种联系是通过大脑网络连接的改变发生的,这表明微生物编程对心理健康的影响.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 发展心理学 发展心理学
背景情况:
- 微生物组-肠-大脑轴对心理健康至关重要.
- 在发育过程中对微生物组与大脑相互作用的研究是有限的.
- 抑郁和焦虑等心理健康问题通常在发育期间表现出来.
研究的目的:
- 研究生命早期微生物形状与大脑特征之间的关系.
- 通过大脑网络的改变,确定微生物对内化症状的贡献.
- 探索潜在的微生物编程对心理健康的影响.
主要方法:
- 这是一项55名参与者的观察性研究.
- 使用休息状态fMRI扫描来得出6岁时的大脑特征.
- 在2岁时分析了便样本 (16S rRNA测序) 以确定微生物特征.
- 在7.5岁时使用稀疏的部分最小平方来链接微生物概况,大脑特征和内化症状.
主要成果:
- 在6岁时确定了与7.5岁时内化症状相关的特定大脑特征.
- 发现了2岁时微生物丰富度与这些大脑特征之间的关联.
- 发现Clostridiales序列和Lachnospiraceae家族中的微生物与通过情绪相关的大脑网络连接变化来内化症状有关.
结论:
- 早期的肠道微生物组组成,特别是Clostridiales和Lachnospiraceae,与儿童中期内化症状有关.
- 这些关联是由大脑网络连接的变化介导的.
- 研究结果表明,早期微生物编程在塑造心理健康轨迹方面可能发挥作用.
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