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Updated: Jan 12, 2026

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通过PUS7对7SK的伪化调节了Pol II转录延长

Yutao Zhao1,2, Hui-Lung Sun1,2, Wenlong Li1,2

  • 1Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.

Nature communications
|October 31, 2025
PubMed
概括

由PUS7对7SK小核RNA (snRNA) 的伪尤里丁 (Ψ) 修改调节了转录. 在7SK中 Ψ的损失增强了RNA聚合酶II的延长,并使结直肠癌细胞对5-FU敏感.

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