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Updated: Jan 12, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
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Published on: August 28, 2012

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通过主细胞信号调节器与受体相互作用的蛋白激酶1进行粉样纤维组合的结构基础

Paula Polonio1,2, Jorge Pedro López-Alonso3,4, Hanxing Jiang3

  • 1Instituto de Química Física Blas Cabrera (IQF-CSIC), Madrid, Spain.

Nature communications
|October 31, 2025
PubMed
概括

研究人员确定了人类RIPK1 (hRIPK1) 粉样纤维的原子结构,揭示了N形折叠对亡信号传递至关重要. 这一发现促进了对功能性粉样蛋白组合和RIPK1-RIPK3相互作用的理解.

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