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阐明机械应力对mRNA-LNP结构的影响的潜在机制

Erika L Jensen1, Ying-Chih Chi1, Rachel Edwards1

  • 1Characterization and Analytical Sciences, Analytical Research and Development, Pfizer, Chesterfield, USA.

Scientific reports
|October 31, 2025
PubMed
概括

长时间动mRNA-脂质纳米颗粒 (LNPs) 可以导致显著的结构变化,包括增加颗粒大小和未封装的RNA释放. 这凸显了了解对LNP稳定性的机械应力对于疫苗开发的重要性.

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