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降胆固醇本土益生菌的选择和潜力:体外和体外研究的见解

Siloni Patial¹, Akshita Sharma¹, Khem Raj¹

¹Department of Microbiology, Panjab University, Basic Medical Sciences (Block-1), South Campus, Chandigarh, 160014, India.

Scientific reports

|October 31, 2025

概括

本土的乳酸细菌 (LAB),特别是乳植物细菌 (Lactiplantibacillus plantarum M10) 显示出显著的降胆固醇效应. 这种益生菌降低了高胆固醇饮食养的老鼠的动脉样硬化风险因素,为心血管健康提供了天然干预措施.

科学领域:

微生物学微生物学
心血管科学心血管科学
营养科学营养科学

背景情况:

动脉样硬化对全球健康造成重大负担,目前的治疗方法,如他类药物,已经显示出局限性.
越来越需要新的自然干预措施来管理心血管健康并减轻动脉样硬化进展.
乳酸细菌 (LAB) 以其潜在的健康益处而闻名,包括胆固醇调节.

研究的目的:

为了评估本土乳酸细菌 (LAB) 隔离物的降胆固醇能力.
在高胆固醇饮食模型中研究Lactiplantibacillus plantarum M10的体外和体内疗效.
评估L. plantarum M10对Sprague Dawley大鼠动脉样硬化风险因素的影响.

主要方法:

在实验室中对14种本土LAB分离物的查,以发现降胆固醇潜力.
在模拟的胃和肠道条件下测试L. plantarum M10.
将L. plantarum M10给Sprague Dawley大鼠进行12周的高胆固醇饮食.
分析血清脂质特征,耐葡萄糖,肝功能,氧化应激标志物,并进行组织学检查.

主要成果:

在实验室中,Lactiplantibacillus plantarum M10表现出最大的降胆固醇潜力 (53.93%) 和在模拟的肠道条件下显著的活性 (50.43%).
在体内给药L. plantarum M10减弱了体重增加,脂肪,并改善了血清脂质谱,葡萄糖耐受性和肝功能.
用L. plantarum M10补充剂减少了氧化应激,改善了肝硬化症,脂肪细胞缩,并维持了高胆固醇饮食养大鼠的动脉形态.

结论:

乳植物菌植物菌M10在降低胆固醇水平方面表现出显著的多因素能力.
这种本土益生菌有效地减轻了与早期动脉样硬化相关的关键风险因素.
L. plantarum M10代表了一种有前途的自然生物干预措施,用于改善心血管健康和控制动脉样硬化.

关键词:

动脉样硬化是一种动脉样硬化.心血管疾病是什么心血管疾病降低胆固醇降低胆固醇高胆固醇的饮食高胆固醇的饮食益生菌益生菌益生菌益生菌益生菌益生菌

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