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与其他方式相比,与激发强度相比,皮肤内电触发电位的试验-重试可靠性

Sara U Júlio¹, Pascale Rüegge², Miriam Schneuwly²

¹Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008, Zurich, Switzerland. sara.uldryjulio@balgrist.ch.

Scientific reports

|October 31, 2025

概括

皮内电唤起电位 (IEEP) 显示出有希望的可靠性来表征脊柱病理,特别是在更高的强度下. 临床使用IEEP的最佳强度需要进一步调查,以获得一致的疼痛评级和神经延迟测量.

科学领域:

神经科学是一个神经科学.
临床神经生理学临床神经生理学
疼痛研究疼痛研究

背景情况:

皮内电唤起潜力 (IEEPs) 为评估脊柱病理提供了一种新的方法.
对IEEP的可靠性对于临床翻译至关重要,需要严格的评估.
将IEEP与已建立的方法比较,例如接触热 (CHEPs) 和针刺 (PEPs) 唤起的潜力是必不可少的.

研究的目的:

为了评估IEEPs的测试-重新测试可靠性.
将IEEP的可靠性与CHEP和PEP进行比较.
为了确定可靠IEEPs的最佳皮肤内电刺激 (IES) 强度.

主要方法:

两项实验使用类内相关系数 (ICC) 和布兰德-阿尔特曼分析评估了测试重复测试的可靠性.
实验1比较IEEP (在2x电探测值,EDT) 与CHEP和PEP.
实验2评估了各种IES强度 (1.5x,2x,4xEDT和0.5mA) 的IEEP.

主要成果:

在2x EDT的IEEP显示出极好的NP幅度可靠性,类似于CHEP和PEP.
在2x EDT时IEEP N-延迟和疼痛评级的可靠性差到相当.
更高的IES强度 (4x EDT,0.5 mA) 显著提高了IEEP N-延迟和疼痛评级的可靠性,达到良好/优秀水平.

结论:

IEEP显示出特征脊柱病理的潜力,NP幅度可靠性在2x EDT时是强大的.
建议使用更高的IES强度 (4x EDT,0.5 mA),以提高IEEP N-延迟和临床环境中的疼痛评级的测试-重新测试可靠性.
需要进一步的研究来优化IEEPs协议,以便在疼痛评估中得到一致的临床应用.

关键词:

皮肤内部电气唤起的潜能.多模式唤起的潜力多种方式.神经生理学神经生理学与疼痛相关的唤起潜力与疼痛相关的唤起潜力.测试反测试可靠性的可靠性

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