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Updated: Jan 12, 2026

Methodology for Accurate Detection of Mitochondrial DNA Methylation
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细胞质TOP3α促进了通过cGAS的线粒体DNA传感

Dongjing Cai1,2, Cheng Chen2,3, Piyanat Meekrathok1,2

  • 1Hunan Key Laboratory of Molecular Precision Medicine, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, China.

EMBO reports
|October 31, 2025
PubMed
概括

细胞质拓聚酶3α (TOP3α) 通过促进cGAS传感来增强线粒体DNA (mtDNA) 触发的先天免疫力. 异常的TOP3α表达或突变会损害这一关键的免疫信号通路.

关键词:
细胞质的TOP3α.炎症 炎症是一种炎症.线粒体DNA是线粒体的DNA.cGAS 是一个气体.

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