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Updated: Jan 12, 2026

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples
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使用常规显微镜使用颜色强度条形码在一轮中进行高复合空间RNA成像

Tianyi Chang1, Shihui Zhao1,2, Kunyue Deng1,2

  • 1Biomedical Pioneering Innovation Center (BIOPIC), Peking University International Cancer Institute, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.

Nature biotechnology
|October 31, 2025
PubMed
概括

通过单回合成像 (PRISM) 在现场对RNA进行分析,可以通过扩大色彩容量,使用标准显微镜进行64倍位RNA成像. 这一突破有助于在各种生物系统中进行详细的空间转录基因分析.

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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