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Updated: Jan 12, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

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综合生理学基础的药理动力学模型与定量系统药理学和毒理学模型,用于疾病群体中的他类药物. 第二部分:MIDD和MIPD应用

Luna Prieto Garcia1,2, Pär Nordell2, Christine Ahlström2

  • 1Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Box 591, SE-75124, Uppsala, Sweden.

The AAPS journal
|October 31, 2025
PubMed
概括

精准医学通过整合基于生理学的药理动力学 (PBPK) 和定量系统药理学 (QSP) 模型来优化药物的疗效和安全性. 这种方法预测了药物相互作用和器官功能障碍的风险,增强了基于模型的药物开发 (MIDD) 和精确剂量 (MIPD).

关键词:
在CKD中,它是最重要的.个性化剂量 个性化剂量肌肉毒性 肌肉毒性基于生理学的药物动力学建模.质量服务提供商QSP

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