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Updated: Jan 12, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

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准备和优化pramipexole化固体分散剂以改善药物释放和生物可用性

Yuanyuan Ding1,2, Zhenkun Su1, Guodong Liang1

  • 1College of Pharmacy, Inner Mongolia Medical University, Hohhot, China.

AAPS PharmSciTech
|October 31, 2025
PubMed
概括

这项研究使用热挤出开发了持续释放的普拉米醇二化 (PPX) 固体分散颗粒. 这种新型配方显著提高了大鼠的PPX生物可用性和大脑积累,为帕金森病提供了有前途的治疗方法.

关键词:
中心复合设计设计的中心复合设计.热挤出方式药物动力学 药物动力学普拉米醇二化固体分散的散发方式

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