细胞癌的检测:诊断尿路生物标志物的系统性审查
Jaycey F Kelly1, Iryna V Samarska1, Bram Ramaekers2
1Department of Pathology, GROW - Research Institute for Oncology & Reproduction, Maastricht University Medical Center, P.O. Box 5800, Maastricht, 6202AZ, The Netherlands.
BMC cancer
|October 31, 2025
概括
尿路生物标志物显示出诊断细胞癌 (RCC) 的前景,多生物标志物面板通常表现优于单个标志物. 在临床使用这些诊断工具之前,外部验证至关重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物标志物发现发现
- 在瘤学瘤学.
背景情况:
- 细胞癌 (RCC) 是最常见的瘤,通常是偶然发现的.
- 通过成像来区分恶性和良性质是具有挑战性的.
- 目前没有尿路生物标志物用于临床RCC诊断,突出需要全面审查.
研究的目的:
- 系统地审查和总结有关RCC诊断尿路生物标志物的现有文献.
- 为了确定细胞癌的潜在诊断性尿路生物标志物.
- 提供关于RCC尿路诊断标记的当前研究概述.
主要方法:
- 在PubMed,Scopus和Web of Science的系统文献搜索符合条件的研究.
- 包括评估成年人偶发性RCC尿路生物标志物的研究,并报告诊断性质.
- 使用修改后的STROBE检查清单评估偏差风险.
主要成果:
- 确定了105个单个生物标记物 (代谢物,蛋白质,miRNA,DNA甲基化标记物) 和29个多生物标记物面板.
- 有前途的诊断标记 (AUC ≥0.80) 包括能量代谢标记,AQP1,PLIN2,miR-122-5p,miR-15a和miR-30c.
- 对已确定有前途的标记物和面板严重缺乏外部验证.
结论:
- 各种尿路生物标志物显示出RCC的有前途的诊断潜力.
- 与单个标记物相比,多生物标记物面板经常显示出优越的诊断能力.
- 单个标记物和面板的外部验证对于临床实施至关重要.
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