移植后糖尿病 (PTDM) 频率,风险因素和结果:单一中心体验
Nazish Fatima1, Zareen Kiran2, Muhammad Tassaduq3
1National Institute of Diabetes and Endocrinology, Dow International Medical College, Dow University of Health Sciences, Gulzar-e- Hijri Road, off Suparco Road, KDA Scheme-33, Karachi, Pakistan. nazzishfatima@gmail.com.
BMC nephrology
|October 31, 2025
概括
移植后糖尿病 (PTDM) 影响超过四分之一的移植患者,导致感染和移植排斥等更糟糕的结果. 早期发现和治疗PTDM对于改善患者的生存和移植功能至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 移植手术 移植手术
背景情况:
- 移植后糖尿病 (PTDM) 是器官移植后的一种严重并发症.
- 风险因素和PTDM的临床后果尚不清楚,特别是在南亚人群中.
- 这项研究调查了巴基斯坦移植接受者的PTDM.
研究的目的:
- 为了确定移植受体中PTDM的频率.
- 确定与PTDM发展相关的移植前风险因素.
- 为了比较PTDM和非PTDM患者之间的临床结果.
主要方法:
- 对121名移植患者 (2018-2021) 的回顾性队列观察性研究.
- 数据收集包括人口统计,移植前的风险因素和移植后的3,6个月和12个月的结果.
- 诊断PTDM遵循国际共识的指导方针;结果在PTDM和非PTDM组之间进行了比较.
主要成果:
- 在研究队列中,有27.3%的人患有PTDM.
- 在PTDM患者中,禁食血糖水平显著上升.
- PTDM与感染率的增加,移植功能的延迟和移植排斥,以及脂质失调的更高患病率有关.
结论:
- PTDM显著恶化了移植后的结果,包括移植功能和易受感染的可能性.
- 需要谨慎管理,以减轻PTDM患者的不良事件.
- 早期检测和有针对性的干预措施对于改善PTDM移植患者的临床结果至关重要.
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