考虑影响估计的再表达变量的重要性,以便在元分析中使用
Leonid Kopylev1, Michael Dzierlenga2
1Center for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, 1200 Pennsylvania Ave, Washington DC, NW, 20460, USA. Kopylev.leonid@epa.gov.
对元分析的再表达方法在正确考虑统计变异性时,对较小的样本大小具有潜在的可靠性. 这与最近的一项研究形成鲜明对比.
科学领域:
- 生物统计学 生物统计学
- 流行病学 流行病学
- 医学研究方法学 医学研究方法学
背景情况:
- 分析通常涉及将多项研究的数据结合起来,当暴露数据经历了转换时,这可能会带来挑战.
- 最近由Linakis等人出版的一本书. 质疑了元分析中再表达方法的可靠性.
- 之前的研究将影响估计视为常数,忽略了它们固有的变化性.
研究的目的:
- 重新评估Linakis等人的结论. 关于在元分析中重新表达方法的可靠性.
- 为了证明在统计分析中将随机变量 (效果估计) 视为常数的影响.
- 评估重新表达方法对于具有不同样本大小的元分析的适当性.
主要方法:
- 这封信标识了Linakis等在Linakis等的具体情况. 在分析中,不考虑影响估计的变化.
- 建议采用统计方法,适当考虑影响估计的固有变化.
- 在考虑随机变量属性的条件下分析重新表达方法的性能.
主要成果:
- 假设效果估计是常数,而不是随机变量,显著影响了前一项研究的结论.
- 当适当考虑统计变异性时,再表达方法在估计观察到的点估计时显示出精细化潜力.
- 重复表达方法似乎适用于采用小到中等样本大小 (高达大约5000个) 的元分析.
结论:
- 由Linakis等人得出的结论. 关于重新表达方法在元分析中不可靠的观点受到质疑.
- 重复表达方法可以适用于元分析,特别是较小的样本大小,只要变化得到统计处理.
- 通过对随机变量进行适当的统计考虑,可以进一步完善再表达技术.
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