在高风险的人类乳头瘤病毒阳性和阴性宫内皮质新生病中比较瘤结果
Saliha Sağnıç1, Serap Fırtına Tuncer2, Hasan Aykut Tuncer1
1Division of Gynecologic Oncology, Department of Gynecology Obstetrics, Akdeniz University, Antalya, Turkey.
概括
高风险的人类乳头瘤病毒 (HR-HPV) 阴性宫内皮质瘤3级 (CIN3) 与HR-HPV阳性CIN3具有类似的复发和癌症风险. 管理和后续行动应该对两个群体都是同等的.
科学领域:
- 妇科 妇科医生 妇科
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 高危人乳头瘤病毒 (HR-HPV) 阴性高度宫内皮质瘤 (CIN) 的临床意义尚不清楚.
- 阴性HR-HPV结果可能来自测试限制或生物因素,如病毒清除或HPV独立途径.
研究的目的:
- 为了比较HR-HPV阳性和HR-HPV阴性女性的复发率和子宫切除率,诊断出CIN3.
- 为了确定HR-HPV-阴性CIN3病例的瘤结果.
主要方法:
- 对712名患有CIN3的女性进行了回顾性多中心队列研究 (2014-2023年).
- 使用Cobas 4800试验进行HR-HPV检测和基因型鉴定.
- 统计分析包括卡普兰-梅尔估计和考克斯回归模型.
主要成果:
- 9% (n=64) 患有CIN3的女性是HR-HPV阴性.
- 与HR-HPV阳性病例相比,HR-HPV阴性状态与复发,癌症进展或子宫切除的风险增加无关.
- 复发率 (6.2%对12.1%) 和宫癌发病率 (2%对1.5%) 在两组之间 (p>0.05) 是可比的.
结论:
- HR-HPV阴性CIN3具有临床意义,需要与HR-HPV阳性CIN3相比的管理和随访.
- HR-HPV阴性CIN3的瘤结局与HR-HPV阳性CIN3相似,表明具有同等的临床意义.
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