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Updated: Jan 12, 2026

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

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应对治疗挑战:沃里康纳的药理动力学和CYP2C19遗传多态性-A病例报告和文献综述

Sadaf Ahmer1, Jessica Bui1,2, Pirathaban Sivabalan3

  • 1Department of Infectious Diseases, Royal North Shore Hospital, St Leonards, NSW, Australia.

British journal of clinical pharmacology
|October 31, 2025
PubMed
概括

在免疫功能低下的患者中,Scedosporium apiospermum感染可能因影响药物代谢的遗传变异而难以用voriconazole治疗. 药物遗传学测试揭示了一种快速代谢基因型,导致治疗次的沃里康纳水平和治疗失败.

关键词:
在CYP2C19的多态化中.斯基多斯波里亚亚亚皮奥斯珀姆 (Scedosporium apiospermum) 是一种精子.抗真菌疗法是一种抗真菌疗法.免疫功能低下的患者.药物遗传学 药物遗传学药物动力学 药物动力学沃里康纳 (Voriconazole) 是一种一种

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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
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