凯尔和Kx血型系统:一个更新
Candice L Davison1, Gregory A Denomme2
11Pathology and Clinical Governance, Australian Red Cross Lifeblood, Brisbane, Queensland, Australia.
Immunohematology
|October 31, 2025
概括
凯尔和Kx血型系统的最新进展揭示了新的抗原和等位基因,影响红细胞膜稳定性和麦克劳德综合征诊断. 分子诊断对于解决模两可,帮助诊断神经退行性综合征至关重要.
科学领域:
- 免疫血液学 免疫血液学
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 凯尔 (ISBT 006) 和Kx (ISBT 019) 血型系统自2015年以来发生了重大更新.
- 新的见解将凯尔糖蛋白与红细胞膜稳定性联系起来.
- 发现包括新型抗原,等位基因和麦克劳德综合征的第一个婴儿诊断.
研究的目的:
- 审查和更新Kell和Kx血型系统的知识.
- 突出最近在抗原,等位基因和相关表型方面的发现.
- 强调分子诊断和新兴技术的作用.
主要方法:
- 2015年以来科学出版物的文献综述.
- 在Kell和XK基因中发现新的抗原和等位基因的分析.
- 讨论分子诊断和新兴技术的进展.
主要成果:
- 凯尔系统现在有38个抗原,其中有编码Kmod和K0表型的新型等位基因.
- XK系统显示与Kx- (无) 现型相关的等位基因增加.
- 分子诊断对于血清学模糊性解决和神经退行性综合征诊断至关重要.
结论:
- 凯尔和Kx血型系统继续扩大,带来新的遗传变异.
- 分子诊断在输血医学和临床诊断中发挥着越来越重要的作用.
- 新兴技术有望更深入地了解Kell和Kx蛋白的功能和相关疾病.
相关概念视频
Blood Types
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Blood Transfusion and Agglutination
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
The ABO Blood Group
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Rh Blood Group
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Blood Typing
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Blood Transfusion
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
