植物性虫药:一种趋势的方法来控制动物的胃肠道疾病
Maria Jamil1, Muhammad Kashif Saleemi1, Mujeeb Ur Rehman2
1Department of Pathology, Faculty of Veterinary Science, University of Agriculture, Faisalabad-38040, Pakistan.
Mini reviews in medicinal chemistry
|October 31, 2025
概括
牲畜对虫的耐药性是一个日益严重的问题. 草药为合成药物提供了可持续的替代品,用于控制反动物的胃肠道寄生虫.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 民族植物学 民族植物学
- 可持续农业 可持续农业
背景情况:
- 牲畜中的虫耐药性对全球粮食生产构成重大经济和可持续性威胁.
- 在反动物中,胃肠道寄生虫会降低生产力,生育力和动物福利,环境和管理因素加剧了这种情况.
- 合成杀虫剂由于耐药性快速发展而面临效率下降.
研究的目的:
- 审查植物衍生的杀虫剂对控制反动物寄生虫感染的疗效和机制.
- 突出草药作为传统合成药物的可持续替代品的潜力.
- 强调将自然解决方案纳入牲畜健康管理.
主要方法:
- 在体外和体内对具有甲虫作用的药用植物的研究的文献综述.
- 对植物化学成分及其对虫的作用机制的分析.
- 评估植物化合物的协同效应及其实际应用.
主要成果:
- 一些药用植物 (例如,Azadirachta indica,Allium sativum) 显示出强大的杀虫活性.
- 植物化学物质向寄生虫的新陈代谢,繁殖和结构完整性.
- 与合成药物相比,草药杀虫剂的毒性降低,副作用更少,耐药性风险更低.
结论:
- 来自植物的杀虫剂为控制反动物寄生虫提供了一个可行的,环保的策略.
- 整合草药可以减少对合成药物的依赖,改善动物健康和农场利能力.
- 对协同效应和实际应用的进一步研究对于可持续的畜牧业生产是有必要的.
相关概念视频
01:28Biological Methods for Microbial Control
770
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
770
01:17Drugs for Treatment of Diarrhea-Predominant IBS
615
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
615
01:20Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
561
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
561
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
410
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
410
01:21Drugs for Treatment of Constipation-Predominant IBS
688
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
688
01:23Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
867
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
867