狼性炎的生物标志物 组织病理学:我们站在哪里?
Valentina Querin1,2, Leonardo Palazzo3, Agnes B Fogo4
1Department of Pathology and Medical Biology, University Medical Center Groningen, The Netherlands.
Arthritis & rheumatology (Hoboken, N.J.)
|October 31, 2025
概括
鉴定狼性炎 (LN) 的非侵入性生物标志物对于患者监测至关重要. 本次审查强调了挑战和五个有前途的生物标志物,包括TGF-β1和PTX3,用于未来临床实践中的验证.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 狼性炎 (LN) 需要持续监测,因为它的疾病过程是可变的.
- 非常需要非侵入性生物标志物来评估LN活动和慢性.
- 目前的诊断方法往往依赖于诸如脏活检之类的侵入性手术.
研究的目的:
- 系统地审查和评估对狼性炎生物标志物的研究质量,与其组织病理相关联.
- 确定阻碍新生物标志物的临床实施的挑战.
- 确定有希望的非侵入性生物标志物,以便在未来对狼性炎进行验证.
主要方法:
- 对活检证明的LN (2012-2024) 成年患者的研究进行了系统的文献搜索.
- 研究的重点是生物标志物和组织学发现 (NIH指数,ISN/RPS类,活跃/慢性病变) 之间的相关性.
- 一个多学科专家小组使用标准化评分系统评估了所选文章的质量.
主要成果:
- 选择了93篇文章,评估了100多个生物标志物.
- 很大一部分 (68%) 的研究被评为质量较差或非常差.
- 五种生物标志物TGF-β1,PTX3,CD163,CD11b和IL-16显示出临床实施的潜力.
结论:
- 方法的异质性和研究质量的适度阻碍了新的LN生物标志物的临床采用.
- 建议对生物标志物进行进一步的研究,这些生物标志物与组织病理特征有很强的相关性.
- 目前,很少有生物标志物符合在狼性炎管理中广泛临床使用所需的高标准.
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