肠道微生物群衍生代谢物与瘤微环境之间的通信
Xinyi Hu1, Bo Li1, Yuanqing Li1
1Department of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Frontiers in immunology
|October 31, 2025
概括
肠道微生物群影响人类的健康和疾病. 肠道微生物及其代谢物可以重塑瘤微环境 (TME),为增强癌症免疫疗法和个性化治疗策略提供新的途径.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群在人类健康和疾病中起着至关重要的作用.
- 瘤微环境 (TME) 是瘤进展的关键.
- 肠道微生物群代谢物越来越多地被认为具有调节TME的潜力.
研究的目的:
- 审查肠道微生物群衍生代谢物和TME之间的相互调节机制.
- 探索这些相互作用的潜力,以改善癌症免疫疗法.
主要方法:
- 关于肠道微生物群,TME和癌症免疫治疗的最新研究的文献综述.
- 分析肠道微生物群代谢物影响TME的机制.
- 在癌症治疗中基于微生物组的干预措施的证据综合.
主要成果:
- 肠道微生物群的代谢物 (例如,SCFA,胆酸) 可以显著重塑TME.
- 基于微生物组的干预措施显示出增强癌症免疫治疗疗效的潜力.
- 肠道微生物群的可变作用使治疗结果的预测变得复杂.
结论:
- 了解肠道微生物群和TME交叉对开发个性化癌症管理至关重要.
- 利用这些相互作用有望促进癌症免疫治疗的发展.
- 需要进一步的研究来优化基于微生物组的癌症治疗策略.
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