循环胆酸和HOMA-IR:来自RoCAV基于人群的研究的横截面结果
Sarah Grossi1, Emanuele Maria Giusti1, Giovanni Veronesi1
1Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy.
禁食循环胆酸 (cBAs) 与老年人胰岛素抵抗有关,而纤维细胞生长因子19 (FGF-19) 则显示出相反的关联. 这些标志物可能会改善2型糖尿病风险预测.
科学领域:
- 内分泌学和新陈代谢学
- 胃肠病学 胃肠病学
- 老年学是一门学科.
背景情况:
- 循环胆汁酸 (cBAs) 是信号分子,激活了法尔内索体X受体 (FXR).
- FXR激活促进纤维细胞生长因子19 (FGF-19) 的分泌,影响胆酸合成,葡萄糖代谢和胰岛素敏感性.
- 老年人群中禁食cBAs,FGF-19和胰岛素耐药性 (HOMA-IR) 之间的关系尚不清楚.
研究的目的:
- 调查禁食循环胆酸 (cBA),FGF-19和胰岛素抵抗 (HOMA-IR) 之间的关联.
- 探索cBAs和FGF-19在改善2型糖尿病 (T2DM) 风险分层方面的潜力.
主要方法:
- 从RoCAV基于人口的研究中对1049名老年参与者 (60-75岁) 的分析.
- 使用UHPLC-MS/MS和FGF-19水平测量了23个循环胆酸 (cBA).
- 使用线性回归和ROC曲线分析评估关联,对共变量进行调整.
主要成果:
- 主要和次要cBA都与HOMA-IR有积极的关联,即使在相互调整后.
- 在相互调整的模型中,FGF-19与HOMA-IR呈现了反向关联.
- 将cBA和FGF-19结合在一起显著改善了T2DM病例的歧视.
结论:
- 初级和二级cBA与老年意大利人的胰岛素耐药性有关.
- 在这个人群中,FGF-19与胰岛素抵抗有负面关联.
- 这些标记物有可能增强T2DM风险分层和了解胆汁酸-葡萄糖代谢.
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