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直接和间接调节骨代谢由乳酸铁素
Yangyang Wu1, Cunxin Zhang2, Chaoliang Lv2
1Clinical Medical College of Shandong Second Medical University, Weifang, China.
Frontiers in endocrinology
|October 31, 2025
概括
乳酸素通过直接的细胞效应和对系统因素的间接影响,积极调节骨代谢. 对乳酸铁和缓释系统的研究为治疗骨科疾病提供了潜力.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 整形外科 整形外科 整形外科
背景情况:
- 乳酸通过直接和间接的机制影响骨代谢.
- 了解这些途径对于开发新的骨病疗法至关重要.
研究的目的:
- 审查乳酸铁素调节骨代谢的机制.
- 为突出乳酸衍生和骨科应用的缓释系统的进步.
主要方法:
- 对直接和间接途径的文献综述.
- 对参与骨细胞分化和亡的信号通路的分析.
- 检查由乳酸铁素影响的系统因素.
主要成果:
- 乳酸直接通过生长因子和信号通路 (例如,IGF,TGF-β,RANKL,NF-κB,MAPK/ERK,PI3K/Akt) 调节骨质细胞,骨质细胞和软质细胞.
- 间接地,乳酸会影响骨肌肉,新陈代谢,肠道微生物群,免疫力和-平衡,有利于骨健康.
- 乳二烯衍生和缓释系统在骨科疾病治疗方面表现有前途.
结论:
- 乳酸对骨代谢的多方面的调节是复杂的,并未完全阐明.
- 对基于乳酸的疗法进行进一步的研究,特别是基于的缓释系统,对于骨科疾病是有必要的.
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