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影响季节性繁殖者生殖效率的分子途径:改善驴子生育能力的前景和影响

Muhammad Faheem Akhtar¹, Shahzad Ali², Faizul Hassan²

¹Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, China.

Frontiers in veterinary science

|October 31, 2025

概括

像驴子这样的季节性繁殖者依赖神经内分泌通路进行繁殖. 环境因素,氧化应激和内分泌干扰物影响生育能力,需要像光周期和黑激素治疗这样的干预措施来改善繁殖成功.

科学领域:

生殖生物学和内分泌学.
动物科学与生殖
环境对生殖的影响.

背景情况:

包括驴在内的季节性繁殖动物的繁殖效率由复杂的神经内分泌和分子通路调节,对环境线索敏感.
由黑激素调节和受光周期影响的下丘脑-垂体-淋巴结核 (HPG) 轴控制淋巴结核释放激素 (GnRH) 的分泌,影响季节性生殖周期.
代谢信号,氧化应激,内分泌干扰化学物质 (EDC) 和益生菌水平是影响生殖功能和生育能力的关键因素.

研究的目的:

审查复杂的分子和神经内分泌机制,控制驴子和其他季节性育种动物的季节性繁殖.
突出环境因素,新陈代谢状态,氧化应激和EDCs在生殖成功中的作用.
探索潜在的干预措施,以提高这些物种的生育力和保护力度.

主要方法:

审查关于季节性繁殖,内分泌学和生殖生理学的现有科学文献.
分析分子通路,包括HPG轴,黑激素信号传递和KNDy神经元.
检查环境敏感性,营养,氧化应激和EDCs对生殖功能的影响.

主要成果:

黑色素水平决定HPG轴的激活或抑制,通过KNDy神经元影响GnRH脉动性,以调节季节性繁殖.
营养素的可用性,氧化应激和EDC暴露显著破坏生殖过程,导致性腺损伤和不孕.
益生菌与淋巴激素和代谢途径相互作用,在季节性生殖适应中发挥作用.

结论:

了解这些分子机制对于改善驴子和其他季节性繁殖动物的生殖结果至关重要.
诸如光周期操纵,黑激素治疗,营养补充剂和抗氧化剂治疗等干预措施显示出增强生育能力的前景.
精子玻璃化,丸免疫学,代谢内分泌学和卵泡动力学方面的进展为生育操纵和保护策略提供了途径.

关键词:

在KNDy神经元中.驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子,驴子垂体垂体-腺轴的下垂体黑激素是什么意思黑激素是什么意思氧化应激是一种氧化应激.生殖效率提高的生殖效率.季节性繁殖季节性繁殖类固醇的产生.

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