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Updated: Jan 12, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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基于结构的设计,用于潜在的IPF治疗的orthosteric和allostericCCR2抑制剂

Gaofei Yan1,2,3, Jianliang Huang1,2,4, Ziyuan Huang5

  • 1Zhangjiajie College Zhangjiajie Hunan China mingshenglei@163.com.

RSC advances
|October 31, 2025
PubMed
概括

研究人员确定了两种新型小分子,化合物17和化合物67,向C-C化学因受体2型 (CCR2) 用于异常性肺纤维化治疗. 这些化合物显示出有前途的抗纤维素作用,为这种致命疾病提供了新的治疗策略.

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