人类腺病毒21型菌株的基因组表征 - 7个PLAD,中国,2023-2024年
Yali Jin1, Naiying Mao1, Xueping Ma2
1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
China CDC weekly
|October 31, 2025
概括
在中国流传的人类腺病毒21型 (HAdV-21) 菌株表现出显著的遗传保存和重组. 加强监测对于管理HAdV-21感染和指导公共卫生战略至关重要.
科学领域:
- 病毒学 病毒学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 哨戒监测表明,中国21型人类腺病毒 (HAdV-21) 的患病率正在上升.
- 了解循环HAdV-21菌株的分子特征对于公共卫生至关重要.
研究的目的:
- 为了阐明目前在中国流传的HAdV-21菌株的分子特征.
- 分析HAdV-21.21的遗传关系,遗传变异和重组模式.
主要方法:
- 来自中国的23个HAdV-21菌株 (2023-2024) 的全基因组测序 (WGS).
- 集成WGS数据与六个国家的50个先前报告的HAdV-21基因组 (1956-2019).
- 综合的遗传学,遗传变异和重组分析.
主要成果:
- HAdV-21菌株被分为亚型HAdV-21a,HAdV-21b和历史的HAdV-21p.
- 最近的中国HAdV-21a/b菌株 (2023-2024) 与全球菌株具有很高的遗传同源性,并具有共同的祖先.
- 再组合的HAdV-21a/b亚型在E4区域获得了HAdV-3衍生的片段.
结论:
- 再组合的HAdV-21a/b亚型在中国共传播,具有显著的遗传保护.
- 加强监测是必要的,以评估疾病负担,并为HAdV-21的预防和控制措施提供信息.
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