临床生物化学概况和急性减补性心力衰竭的结果
Diksha Gupta1, Sunita Gupta1, Shanker Deep Sondhi1
1General Medicine, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, IND.
Cureus
|October 31, 2025
概括
印度的急性脱补偿性心力衰竭 (ADHF) 显示了保留和减少喷射率 (EF) 组之间的多样性. 尽管风险因素和并发症存在差异,但住院死亡率仍然相似,这凸显了需要个性化ADHF管理的需要.
科学领域:
- 心脏病学 心脏病学
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 急性不补偿性心力衰竭 (ADHF) 是一个日益严重的全球健康挑战,特别是在印度,死亡率和住院率很高.
- 根据射出分数 (EF) 了解ADHF的独特特征对于有效的患者管理至关重要.
研究的目的:
- 为了比较风险因素,临床和生物化学概况,以及印度人口中ADHF患者的医院治疗结果,保留和减少喷射分数 (EF).
- 解决印度关于ADHF患者特征和结果数据中的重大缺口.
主要方法:
- 一项涉及连续100名被诊断患有ADHF的成年患者的横截面观察研究.
- 排除标准包括先天性心脏病,慢性心肺病和风湿性心脏病.
- 数据收集包括详细的病史,临床检查,调查和随访直到出院或死亡,使用SPSS v26.0.0.进行分析.
主要成果:
- 研究群体包括52%的心力衰竭与减少喷射率 (HFrEF) 和48%的心力衰竭与保存喷射率 (HFpEF),平均年龄为62.3岁,男性占主导地位.
- 高血压,肥胖和COPD在HFpEF组中更为普遍,而贫血和败血症是常见的导致因素.
- 增加的白细胞总计数 (TLC),N-终端亲B型尿性 (NT-proBNP),血清肌素和休克与较差的结果有关,肌素是强烈的死亡率预测因子.
结论:
- 患有ADHF的患者表现出多样化的临床生物化学概况和高的并发症负担,保留和减少EF组之间存在显著差异.
- 在两个EF组之间,住院死亡率没有显著差异.
- 除了EF之外的全面风险评估对于ADHF的及时和个性化管理策略至关重要.
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